Serum Immunoglobulin Levels (IgG, IgM, IgA, IgE)


Age
IgG (mg/dL)
IgM (mg/dL)
IgA (mg/dL)
IgE (IU/mL)
Cord blood (term)------
1121 (636–1606)----------
13 (6.3–25)----------
2.3 (1.4–3.6)----------
0.22 (0.04–1.28)----------
1 mo
503 (251–906)
45 (20–87)
13 (1.3–53)

6 wk



0.69 (0.08–6.12)
2 mo
365 (206–601)
46 (17–105)
15 (2.8–47)

3 mo
334 (176–581)
49 (24–89)
17 (4.6–46)
0.82 (0.18–3.76)
4 mo
343 (196–558)
55 (27–101)
23 (4.4–73)

5 mo
403 (172–814)
62 (33–108)
31 (8.1–84)

6 mo
407 (215–704)
62 (35–102)
25 (8.1–68)
2.68 (0.44–16.3)
7–9 mo
475 (217–904)
80 (34–126)
36 (11–90)
2.36 (0.76–7.31)
10–12 mo
594 (294–1069)
82 (41–149)
40 (16–84)

1 yr
679 (345–1213)
93 (43–173)
44 (14–106)
3.49 (0.80–15.2)
2 yr
685 (424–1051)
95 (48–168)
47 (14–123)
3.03 (0.31–29.5)
3 yr
728 (441–1135)
104 (47–200)
66 (22–159)
1.80 (0.19–16.9)
4–5 yr
780 (463–1236)
99 (43–196)
68 (25–154)
8.58 (1.07–68.9)[]
6–8 yr
915 (633–1280)
107 (48–207)
90 (33–202)
12.89 (1.03–161.3)[]
9–10 yr
1007 (608–1572)
121 (52–242)
113 (45–236)
23.6 (0.98–570.6) [§]
14 yr



20.07 (2.06–195.2)
Adult
994 (639–1349)
156 (56–352)
171 (70–312)
13.2 (1.53–114)
IgE data for 4 yr. IgE data for 7 yr. § IgE data for 10 yr.

Immunoglobulins Mayo.png
in mg/dL

Note
  • Total Ig level is net of production, consumption, and loss
  • Half lives
    • IgG(1,2,4) 23 days
    • IgG(3) 8-9 days
    • IgA 6 days
    • IgM 5 days
    • IgE 2.5 days
      • Omalizumab (IgG1) binds to IgE and increases its half-life, resulting in increased total IgE level after starting treatment


Serum IgG Subclass Levels

Age (yr)
IgG1 (mg/dL)
IgG2 (mg/dL)
IgG3 (mg/dL)
IgG4 (mg/dL)
0.5–1-- ----
290 (140–620)----------
58 (41–130)----------
41 (11–85)----------
0.2 (0–0.8)----------
1–1.5
350 (170–650)
62 (40–140)
42 (12–87)
3 (0–26)
1.5–2
400 (220–720)
80 (50–180)
44 (14–91)
7 (0–41)
2–3
450 (240–780)
95 (55–200)
46 (15–93)
14 (0–69)
3–4
480 (270–810)
115 (65–220)
48 (16–96)
20 (1–94)
4–6
500 (300–840)
130 (70–250)
50 (17–97)
26 (2–116)
6–9
570 (350–910)
170 (85–330)
54 (20–100)
37 (3–158)
9–12
600 (370–930)
210 (10–400)
58 (22–109)
47 (4–190)
12–18
580 (370–910)
260 (110–480)
63 (24–116)
49 (5–196)
Adult
500 (280–800)
300 (115–570)
64 (24–120)
35 (5–125)


Combined Chart (Igs and subclasses)

Age of healthy donors IgG
g/L
IgG1
g/L
IgG2
g/L
IgG3
g/L
IgG4
g/L
IgA
g/L
IgA1
g/L
IgA2
g/L
IgM
g/L
0– <5 months 1.0–1.34 0.56–2.15 ≤0.82 0.07.6–8.23 ≤ 0.198 0.07–0.37 0.10–0.34 0.004–0.055 0.26–1.22
5– <9 months 1.64–5.88 1.02–3.69 ≤ 0.89 0.119–0.740 ≤ 0.208 0.16–0.50 0.14–0.41 0.015–0.062 0.32–1.32
9– <15 months 2.46–9.04 1.60–5.62 0.24–0.98 0.173–0.637 ≤ 0.220 0.27–0.66 0.20–0.50 0.028–0.070 0.40–1.43
15– <24 months 3.13–11.70 2.09–7.24 0.35–1.05 0.219–0.550 ≤ 0.230 0.36–0.79 0.24–0.58 0.039–0.077 0.46–1.52
2– <4 years 2.95–11.56 1.58–7.21 0.39–1.76 0.170–0.847 0.004–0.491 0.27–2.46 0.16–1.62 0.013–0.311 0.37–1.84
4– <7 years 3.86–14.70 2.09–9.02 0.44–3.16 0.108–0.949 0.008–0.819 0.29–2.56 0.17–1.87 0.011–0.391 0.37–2.24
7– <10 years 4.62–16.82 2.53–10.19 0.54–4.35 0.085–10.26 0.010–1.087 0.34–2.74 0.21–2.21 0.014–0.480 0.38–2.51
10– <13 years 5.03–15.80 2.80–10.30 0.66–5.02 0.115–10.53 0.010–1.219 0.42–2.95 0.27–2.50 0.026–0.534 0.41–2.55
13– <16 years 5.09–15.80 2.89–9.34 0.82–5.16 0.200–10.32 0.007–1.217 0.52–3.19 0.36–2.75 0.047–0.551 0.45–2.44
16– <18 years 4.87–13.27 2.83–7.72 0.98–4.86 0.313–0.976 0.003–1.110 0.60–3.37 0.44–2.89 0.066–0.543 0.49–2.01
≥18 years 7.67–15.90 3.41–8.94 1.71–6.32 0.184–10.60 0.024–1.210 0.61–3.56 0.50–3.14 0.097–1.560 0.37–2.86



IgE



Total serum IgE (IU/mL)
Age Gender Geometric mean Upper 95% confidence limit
6–14 years M
F
42.7
43.3
527
344
15–24 years M
F
33.6
18.6
447
262
25–34 years M
F
16.8
16.6
275
216
35–44 years M
F
21.7
19.3
242
206
45–54 years M
F
19.2
13.3
254
177
55–64 years M
F
21.3
11.7
354
148
65–74 years M
F
21.2
11.5
248
122
>75 years M
F
18.4
9.2
219
124
6–75 years all M
all F
22.9
14.7
317
189

Total IgE reference intervals.png
Mayo IgE.png
  • Serum levels of IgE greater than +1SD for age would be consistent with the presence of allergic disease

Note:
  • 1 IU/mL = 2.4 ng/mL
  • 1 kUA/L of specific IgE has been shown to be equivalent to 1 kU/L of total IgE in the ImmunoCAP system


Protective Vaccination Antibody Levels

Protective_vaccination_Ab_levels.png


T and B Lymphocytes in Peripheral Blood

(10th to 90th percentile)
Age
CD3 Count (%)
CD4 count (%)
CD8 Count (%)
CD19 Count (%)
0–3 mo-------
2.50–5.50 (53–84)----------
1.60–4.00 (35–64)----------
0.56–1.70 (12–28)----------
0.12–2.10 (14–76)
3–6 mo
2.50–5.60 (51–77)
1.80–4.00 (35–56)
0.59–1.60 (12–23)
0.00–2.80 (00–84)
6–12 mo
1.90–5.90 (49–76)
1.40–4.30 (31–56)
0.50–1.70 (12–24)
0.02–2.30 (01–80)
1–2 yr
2.10–6.20 (53–75)
1.30–3.40 (32–51)
0.62–2.00 (14–30)
0.00–2.30 (00–80)
2–6 yr
1.40–3.70 (56–75)
0.70–2.20 (28–47)
0.49–1.30 (16–30)
0.02–1.40 (02–76)
6–12 yr
1.20–2.60 (60–76)
0.65–1.50 (31–47)
0.37–1.10 (18–35)
0.00–0.74 (00–67)
12–18 yr
1.00–2.20 (56–84)
0.53–1.30 (31–52)
0.33–0.92 (18–35)
0.00–0.39 (00–60)
Adult
0.70–2.10 (55–83)
0.30–1.40 (28–57)
0.20–0.90 (10–39)
0.10–0.50 (6–19)
Absolute counts (number of cells per microliter × 10-3)


Serum Complement Levels

Age
C3 (mg/dL)
C4 (mg/dL)
Cord blood (term)-----
83 (57–116)----------
13 (6.6–23)-------
1 mo
83 (53–124)
14 (7.0–25)
2 mo
96 (59–149)
15 (7.4–28)
3 mo
94 (64–131)
16 (8.7–27)
4 mo
107 (62–175)
19 (8.3–38)
5 mo
107 (64–167)
18 (7.1–36)
6 mo
115 (74–171)
21 (8.6–42)
7–9 mo
113 (75–166)
20 (9.5–37)
10–12 mo
126 (73–180)
22 (12–39)
1 yr
129 (84–174)
23 (12–40)
2 yr
120 (81–170)
19 (9.2–34)
3 yr
117 (77–171)
20 (9.7–36)
4–5 yr
121 (86–166)
21 (13–32)
6–8 yr
118 (88–155)
20 (12–32)
9–10 yr
134 (89–195)
22 (10–40)
Adult
125 (83–177)
28 (15–45)
Numbers in parentheses are the 95% confidence intervals



Blood Eosinophils


Blood absolute eosinophil count (x 10^9/L)---
Blood absolute eosinophil count (/mm3)---
Normal -------
<0.5 (often <5% of leukocytes)
<500
Eosinophilia
>0.5
>500
Mild
>0.5-1.5
>500-1500
Hypereosinophilia-----
>1.5
>1500
Moderate hypereosinophilia-----
>1.5-5
>1500-5000
Severe hypereosinophilia-----
>5
>5000
  • Blood eosinophil count >1.5 x 10^9 is classically considered the level above which organ damage is more likely to occur
    • Note that tissue eosinophilia with potential for organ damage may be present with a normal blood count, and vice versa
    • Eosinophil count may be suppressed (masked) by endogenous (e.g. cortisol stress response to infection) or exogenous corticosteroids



Serum Tryptase Levels


Total (ng/mL)-----
Mature
Ratio---
Normal
<11.5
<1

Anaphylaxis
11.5
>1
10
Mastocytosis-----
20
± elevated-----
20

  • Standard clinical assay measures total tryptase (sum of pro and mature forms of alpha and beta tryptase) and reflects total mast cell number + mast cell degranulation (assay for mature tryptase reflecting pure mast cell degranulation in not available clinically)
  • Median serum tryptase levels are highest in infants under 3 mo (6.12±3.47 mcg/L) and gradually fall to pediatric/adult levels by 9-12 months (3.85 ± 1.8 mcg/L)
  • Atopy is associated with even higher tryptase levels in infants <3 mo (14.20±10.22 mcg/L)




References