Recent Changes

Monday, August 24

  1. file Mast cell disorder algo Akdis.png (deleted) uploaded Deleted File
    4:40 pm

Friday, October 10

  1. page PCN Allergy edited ... AX = amoxicillin MDM = minor determinant mixture Cross-reactivity table PCN Serum Sickness…
    ...
    AX = amoxicillin
    MDM = minor determinant mixture
    Cross-reactivity tablePCN Serum Sickness
    Cephalosporin (Ceclor) related serum sickness

    Cross-reactivity Between β-lactams
    Reaction to cephalosporins
    ...
    10% to cephalexin
    Should also avoid cefaclor, cephradine, cephaloglycin, and loracarbef, which have same R-group side chain as cephalexin
    Note regarding serum-sickness:
    All PCNs should probably be avoided if the patient has a history of serum sickness associated with a PCN in the past
    Serum sickness-like reactions to cefaclor and probably other cephalosporins do not prohibit the administration of PCN

    Cephalosporin in PCN-allergic Patients
    {cephalosporin_in_PCN_allergy.png}
    ...
    {Safely Diagnosing Clinically Significant Penicillin Allergy Using Only Penicilloyl-Poly-Lysine, Penicillin, and Oral Amoxicillin - Macy JACI IP 2013.pdf}
    {Antibiotic Allergies in Children and Adults- From Clinical Symptoms to Skin Testing Diagnosis - JACI IP 2014.pdf}
    {PCN serum sickness cross-reactivity - AAAAI Ask The Expert 2014.pdf}
    (view changes)
    6:51 am

Monday, June 23

  1. page Omalizumab (Xolair) edited ... Chronic idiopathic urticaria Europe: Now eligible if baseline IgE 30-1500 IU/mL {EU_xolai…
    ...
    Chronic idiopathic urticaria
    Europe:
    Now eligible if baseline IgE 30-1500 IU/mL
    {EU_xolair_indications.png}
    Notes:
    (view changes)
    5:51 pm
  2. page Omalizumab (Xolair) edited ... Calculate Dose (Asthma) Determined by body weight and the levels of serum IgE (0.016 mg/kg pe…
    ...
    Calculate Dose (Asthma)
    Determined by body weight and the levels of serum IgE (0.016 mg/kg per IU/mL of IgE per month)
    Following tables are from manufacturer package insert:For omalizumab to cause a sufficient reduction in IgE levels (i.e., to a target level of <50 ng/mL), dosing needs to be at a molar excess of approximately 15-fold over baseline IgE. Based on these measurements, 75-600 mg of omalizumab may be needed for each administration, with a maximum recommended dose of 375 mg every 2 weeks in the United States and 600 mg every 2 weeks in the European Union
    US (FDA) Dosing Table

    {Xolair_dose_chart.png}
    {xolair_dose_nejm.png}
    ICATA Study
    Pediatric dosing (6-20 years old) from the Inner-City Anti-IgE Therapy for Asthma (ICATA) Study
    {Pediatric_Xolair_Dosing_ICATA.png}
    EU Novartis Dosing Table
    {Xolair EU dosing q4 weeks.png}
    {Xolair EU dosing q2 weeks.png}

    Note: if patient calculated to receive omalizumab Q2 weeks but is unable to receive injections due to difficulty adhering to this schedule, can consider giving twice the dose once per month instead. For example, patient calculated to receive omalizumab 225 mg Q2 weeks may receive dose as 450 mg monthly
    Administration
    (view changes)
    5:47 pm

Monday, June 2

  1. page Food Allergens in Medications edited {food allergens in medications.png} References {Potential food allergens in medications - JACI…
    {food allergens in medications.png}
    References
    {Potential food allergens in medications - JACI 2014.pdf}

    (view changes)
    8:47 pm

More